List of Publications

Published

2024

Florian Buerger, Daanya Salmanullah, Lorrin Liang, Victoria Gauntner, Kavita Krueger, Maggie Qi, Vineeta Sharma, Alexander Rubin, David Ball, Katharina Lemberg, Ken Saida, Lea Maria Merz, Sanja Sever, Biju Issac, Liang Sun, Sergio Guerrero-Castillo, Nephrotic Syndrome Study Network (NEPTUNE), Alexis C. Gomez, Michelle T. McNulty, Matthew G. Sampson, Mohamed H. Al-Hamed, Mohammed M. Saleh, Mohamed Shalaby, Jameela Kari, James P. Fawcett, Friedhelm Hildebrandt, Amar J. Majmundar. Recessive variants in the intergenic NOS1AP-C1orf226 locus cause monogenic kidney disease responsive to anti-proteinuric treatment. medRxiv (2024) (doi:https://doi.org/10.1101/2024.03.17.24303374.)

2023

McMillen TS, Leslie A, Chisholm K, Penny S, Gallant J, Cohen A, Drucker A, Fawcett JP, Pinto DM. A large-scale, targeted metabolomics method for the analysis and quantification of metabolites in human plasma via liquid chromatography-mass spectrometry. Anal Chim Acta. (2023) 1279:341791. PMID: 37827685

Diab AM, Wigerius M, Quinn DP, Qi J, Shahin I, Paffile J, Krueger K, Karten B, Krueger SR, Fawcett JP. NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation.  J Neurosci. (2023) 43(6):885-901. PMID: 36535770 

2022

Stanton-Turcotte D, Hsu K, Moore SA, Yamada M, Fawcett JP, Iulianella A. Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development. J Neurosci. (2022) 42(19):3931-3948.  PMID: 35379703 

Thiry L, Lemaire C, Rastqar A, Lemieux M, Peng J, Ferent J, Roussel M, Beaumont E, Fawcett JP, Brownstone RM, Charron F, Bretzner F. Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype. eNeuro. (2022) 9(2):ENEURO.0216-18.2021. PMID: 35115383 

2020

Wigerius M, Quinn D, Fawcett JP. Emerging roles for angiomotin in the nervous system. Sci Signal. (2020) 13(655):eabc0635. PMID: 33109746

2019

Quinn DP, Kolar A, Harris SA, Wigerius M, Fawcett JP, Krueger SR. The Stability of Glutamatergic Synapses Is Independent of Activity Level, but Predicted by Synapse Size. Front Cell Neurosci. (2019) 13:291.  PMID: 31316356 

2018

Stairs CW, Eme L, Muñoz-Gómez SA, Cohen A, Dellaire G, Shepherd JN, Fawcett JP, Roger AJ. Microbial eukaryotes have adapted to hypoxia by horizontal acquisitions of a gene involved in rhodoquinone biosynthesis. Elife. (2018) 7:e34292. PMID: 29697049 

Wigerius M, Quinn D, Diab A, Clattenburg L, Kolar A, Qi J, Krueger SR, Fawcett JP. The polarity protein Angiomotin p130 controls dendritic spine maturation. J Cell Biol. (2018) 217(2):715-730.  PMID: 29317530 

2017

Cohen A, Ross NW, Smith PM, Fawcett JP. Analysis of 17β-estradiol, estriol and estrone in American eel (Anguilla rostrata) tissue samples using liquid chromatography coupled to electrospray differential ion mobility tandem mass spectrometry. Rapid Commun Mass Spectrom. (2017) 31(10):842-850. PMID: 28295771

Alzahrani F, Clattenburg L, Muruganandan S, Bullock M, MacIsaac K, Wigerius M, Williams BA, Graham ME, Rigby MH, Trites JR, Taylor SM, Sinal CJ, Fawcett JP, Hart RD. The Hippo component YAP localizes in the nucleus of human papilloma virus positive oropharyngeal squamous cell carcinoma. J Otolaryngol Head Neck Surg. (2017) 46(1):15. PMID: 28222762

Quinn DP, Kolar A, Wigerius M, Gomm-Kolisko RN, Atwi H, Fawcett JP, Krueger SR. Pan-neurexin perturbation results in compromised synapse stability and a reduction in readily releasable synaptic vesicle pool size. Sci Rep. (2017) 7:42920. PMID: 28220838 

2016

Dranse HJ, Muruganandan S, Fawcett JP, Sinal CJ. Adipocyte-secreted chemerin is processed to a variety of isoforms and influences MMP3 and chemokine secretion through an NFkB-dependent mechanism. Mol Cell Endocrinol. (2016) 436:114-29. PMID: 27461525

Cohen AM, Soto AJ, Fawcett JP. Determination of Flow Rates in Capillary Liquid Chromatography Coupled to a Nanoelectrospray Source using Droplet Image Analysis Software. Anal Chem. (2016) 88(15):7476-80.  PMID: 27351615

2015

Clattenburg L, Wigerius M, Qi J, Rainey JK, Rourke JL, Muruganandan S, Sinal CJ, Fawcett JP. NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling. Mol Cell Biol. (2015) 35(13):2265-77.  PMID: 25918243 

Lane C, Qi J, Fawcett JP. NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits. J Neurochem. (2015) 134(6):1008-14.  PMID: 25913325 

Kai F, Fawcett JP, Duncan R. Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration. Oncotarget. (2015) 6(13):11162-74.  PMID: 25883213 

Blacklaws J, Deska-Gauthier D, Jones CT, Petracca YL, Liu M, Zhang H, Fawcett JP, Glover JC, Lanuza GM, Zhang Y. Sim1 is required for the migration and axonal projections of V3 interneurons in the developing mouse spinal cord. Dev Neurobiol. (2015) 75(9):1003-17.  PMID: 25652362

Toma JS, Shettar BC, Chipman PH, Pinto DM, Borowska JP, Ichida JK, Fawcett JP, Zhang Y, Eggan K, Rafuse VF. Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons. J Neurosci. (2015) 35(3):1291-306. PMID: 25609642 

2010

Soundararajan P, Fawcett JP*, Rafuse VF*. Guidance of postural motoneurons requires MAPK/ERK signaling downstream of fibroblast growth factor receptor 1. J Neurosci. (2010)  30(19):6595-606. PMID: 20463222 

Richier L, Williton K, Clattenburg L, Colwill K, O'Brien M, Tsang C, Kolar A, Zinck N, Metalnikov P, Trimble WS, Krueger SR, Pawson T, Fawcett JP. NOS1AP associates with Scribble and regulates dendritic spine development. J Neurosci. (2010) 30(13):4796-805. PMID: 20357130 

2009

Schmoranzer J, Fawcett JP, Segura M, Tan S, Vallee RB, Pawson T, Gundersen GG. Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration. Curr Biol. (2009) 19(13):1065-74. PMID: 19540120 

2008

Moser SL, Harron SA, Crack J, Fawcett JP, Cowley EA. Multiple KCNQ potassium channel subtypes mediate basal anion secretion from the human airway epithelial cell line Calu-3. J Membr Biol. (2008) 221(3):153-63. PMID: 18264812

2007

Fawcett JP, Georgiou J, Ruston J, Bladt F, Sherman A, Warner N, Saab BJ, Scott R, Roder JC, Pawson T. Nck adaptor proteins control the organization of neuronal circuits important for walking. Proc Natl Acad Sci U S A. (2007)104(52):20973-8. PMID: 18093944 

Hardy WR, Li L, Wang Z, Sedy J, Fawcett J, Frank E, Kucera J, Pawson T. Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science. (2007) 317(5835):251-6. PMID: 17626887 

2006

Chan JR, Jolicoeur C, Yamauchi J, Elliott J, Fawcett JP, Ng BK, Cayouette M. The polarity protein Par-3 directly interacts with p75NTR to regulate myelination. Science. 2006 314(5800):832-6. PMID: 17082460

Aranda V, Haire T, Nolan ME, Calarco JP, Rosenberg AZ, Fawcett JP, Pawson T, Muthuswamy SK. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol. (2006) 8(11):1235-45. PMID: 17060907

Wells CD*, Fawcett JP*, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell. (2006) 125(3):535-48. PMID: 16678097 

2005

Wiggin GR*, Fawcett JP*, Pawson T. Polarity proteins in axon specification and synaptogenesis. Dev Cell. (2005) 8(6):803-16. PMID: 15935771 

2004

Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol. (2004) 14(16):1436-50. PMID: 15324660 

2003

Plant PJ*, Fawcett JP*, Lin DC, Holdorf AD, Binns K, Kulkarni S, Pawson T.  A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol. 2003 5(4):301-8. PMID: 12629547

2000

Fawcett J, Pawson T. Signal transduction. N-WASP regulation--the sting in the tail. Science. (2000) 290(5492):725-6. PMID: 11184204

Lin D, Edwards AS, Fawcett JP, Mbamalu G, Scott JD, Pawson T. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol. (2000) 2(8):540-7. PMID: 10934475